biological networks

*Alberto Castellini, Vincenzo Manca and Mauro Zucchelli*

**Natural Computing**

This webpage presents supplementary material and comparison between results proposed in the current paper (called *CastelliniEtAl2013* in the following) and results proposed in *CastelliniEtAl2012*.

**References:**

*CastelliniEtAl2012*: A. Castellini, V. Manca, and M. Zucchelli. *Towards an evolutionary procedure for reverse-engineering biological networks. *LNCS 7597, pages 271-285. Springer, 2012.

*CastelliniEtAl2013*: A. Castellini, V. Manca, and M. Zucchelli. *An evolutionary procedure for inferring MP systems regulation functions of biological networks. *Natural Computing. Submitted.

*CastelliniEtAl2013*:

*CastelliniEtAl2012*:

*CastelliniEtAl2013*(dynamics of experiment 7):

*CastelliniEtAl2012*(dynamics of experiment 2):

*CastelliniEtAl2012*(fluxes of experiment 2):

*CastelliniEtAl2013*(fluxes of experiment 7):

*Real fluxes*(generating the observed dynamics)

Columns represent primitive functions, rows represent single tests (i.e., experiments) of the evolutionary procedure. Cell i,j is colored from blue to red according to the coefficient assigned to the j-th primitive function in the i-th experiment.

*CastelliniEtAl2013*(heat maps of experiment 7):

*CastelliniEtAl2012*(heat maps of experiment 2):

For each regressor (row) and regulation function (column) it is reported the number of tests in which the regressor has been selected for this regulation function (# sel) and the mean and standard deviation of coefficients assigned to that regressor (mu/sigma).

*CastelliniEtAl2013*(heat maps of experiment 7):

*CastelliniEtAl2012*(heat maps of experiment 2):

Columns represent primitive functions, rows represent single tests of the evolutionary procedure. Cell i,j is colored from blue to red according to the sum of coefficients assigned to the j-th primitive function by all the regulation functions which directly affect the substance, in the i-th test of the evolutionary procedure.

*CastelliniEtAl2013*(heat maps of experiment 7):

*CastelliniEtAl2012*(heat maps of experiment 2):

For each regressor (row) and substance (column) it is reported the number of tests in which the regressor has been selected in a regulation function which directly influences that substance concentration (# sel) and the mean and standard deviation of the sum of coefficients assigned to that regressor in a regulation function which directly influences that substance concentration (mu/sigma).

*CastelliniEtAl2013*(heat maps of experiment 7):

*CastelliniEtAl2012*(heat maps of experiment 2):